Our Clinical Trials

SpringWorks Therapeutics is conducting clinical trials to evaluate the safety and efficacy of our investigational therapies, both alone and in combination with other therapies, for patients with rare tumors and advanced solid tumors.

For more information, follow the links below to the study listings on clinicaltrials.gov. Medical professionals may also email us at clinical@springworkstx.com for more information about study participation. Patients and families should speak to their physician to ask about whether a study is right for them.

Desmoid Tumors

SpringWorks is enrolling patients in a Phase 3 trial for patients with desmoid tumors, which are rare and debilitating soft-tissue tumors that can cause severe pain and disfigurement.

The DeFi trial is evaluating nirogacestat, an oral, selective, small molecule gamma-secretase inhibitor in adult patients with progressing desmoid tumors.

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Neurofibromatosis Type 1-Associated Plexiform Neurofibromas

SpringWorks is enrolling patients in a Phase 2b trial for patients with neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN), which are rare and devastating tumors that can cause severe pain, disfigurement and functional impairment.

The ReNeu trial is evaluating mirdametinib, an oral small molecule designed to inhibit MEK1 and MEK2, in patients two years of age and older with an inoperable NF1-PN causing significant morbidity.

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Advanced or Refractory Solid Tumors that Harbor RAS Mutations, RAF Mutations or Other MAPK Pathway Aberrations

Patients with advanced or refractory solid tumors that harbor RAS mutations, RAF mutations and other MAPK pathway aberrations are being enrolled in a Phase 1b trial.

The study is evaluating the safety, tolerability and preliminary efficacy of combining BeiGene’s investigational RAF dimer inhibitor, lifirafenib (BGB-283) and SpringWorks Therapeutics’ investigational MEK inhibitor, mirdametinib, in patients with advanced solid tumors.

The trial is being administered by BeiGene under a global clinical collaboration agreement between SpringWorks Therapeutics and BeiGene.

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